MovDisordV3, Main, Exploration, bibRecord, 001E50

Anatomical differences between CBS‐corticobasal degeneration and CBS‐Alzheimer's disease

Identifieur interne : 001E50 ( Main/Exploration ); précédent : 001E49; suivant : 001E51

Anatomical differences between CBS‐corticobasal degeneration and CBS‐Alzheimer's disease

Auteurs : Keith A. Josephs [États-Unis] ; Jennifer L. Whitwell [États-Unis] ; Bradley F. Boeve [États-Unis] ; David S. Knopman [États-Unis] ; Ronald C. Petersen [États-Unis] ; William T. Hu [États-Unis] ; Joseph E. Parisi [États-Unis] ; Dennis W. Dickson [États-Unis] ; Clifford R. Jack Jr. [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-07-15.

RBID : ISTEX:DFF9EA95A5680D542D54948AC00515235953F5E4

Descripteurs français

Pascal (Inist)
- Dégénérescence, Démence d'Alzheimer, Morphométrie, Pathologie du système nerveux, Voxel.

English descriptors

KwdEn :
- Aged, Alzheimer Disease (pathology), Alzheimer disease, Alzheimer's disease, Basal Ganglia (pathology), Basal Ganglia Diseases (pathology), Brain Mapping, Cerebral Cortex (pathology), Degeneration, Female, Humans, Imaging, Three-Dimensional (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Morphometry, Nervous system diseases, Neuropsychological Tests, Retrospective Studies, Voxel, corticobasal degeneration, corticobasal syndrome, region‐of‐interest, voxel‐based morphometry.
MESH :
- methods : Imaging, Three-Dimensional, Magnetic Resonance Imaging.
- pathology : Alzheimer Disease, Basal Ganglia, Basal Ganglia Diseases, Cerebral Cortex.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Retrospective Studies.

Abstract

We compare patterns of gray matter loss on MRI in subjects presenting as corticobasal syndrome (CBS) with Alzheimer disease pathology (CBS‐AD) to those presenting as CBS with corticobasal degeneration pathology (CBS‐CBD). Voxel‐based morphometry was used to compare patterns of gray matter loss in pathologically confirmed CBS‐AD subjects (n = 5) and CBS‐CBD subjects (n = 6) to a group of healthy controls (n = 20), and to each other. Atlas based parcellation using the automated anatomic labeling atlas was also utilized in a region‐of‐interest analysis to account for laterality. The CBS‐AD subjects were younger at the time of scan when compared with CBS‐CBD subjects (median: 60 years vs. 69; P = 0.04). After adjusting for age at time of MRI scan, the CBS‐AD subjects showed loss in posterior frontal, temporal, and superior and inferior parietal lobes, while CBS‐CBD showed more focal loss predominantly in the posterior frontal lobes when compared with controls. In both CBS‐AD and CBS‐CBD groups, there was basal ganglia volume loss, yet relative sparing of hippocampi. On direct comparisons between the two subject groups, CBS‐AD showed greater loss in both temporal and inferior parietal cortices than CBS‐CBD. No regions showed greater loss in the CBS‐CBD group compared to the CBS‐AD group. These findings persisted when laterality was taken into account. In subjects presenting with CBS, prominent temporoparietal, especially posterior temporal and inferior parietal, atrophy may be a clue to the presence of underlying AD pathology. © 2010 Movement Disorder Society

Url:

DOI: 10.1002/mds.23062

Affiliations:

Le document en format XML

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<term>Basal Ganglia (pathology)</term>
<term>Basal Ganglia Diseases (pathology)</term>
<term>Brain Mapping</term>
<term>Cerebral Cortex (pathology)</term>
<term>Degeneration</term>
<term>Female</term>
<term>Humans</term>
<term>Imaging, Three-Dimensional (methods)</term>
<term>Magnetic Resonance Imaging (methods)</term>
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<term>Middle Aged</term>
<term>Morphometry</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Retrospective Studies</term>
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<term>corticobasal degeneration</term>
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<term>region‐of‐interest</term>
<term>voxel‐based morphometry</term>
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<term>Magnetic Resonance Imaging</term>
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<front><div type="abstract" xml:lang="en">We compare patterns of gray matter loss on MRI in subjects presenting as corticobasal syndrome (CBS) with Alzheimer disease pathology (CBS‐AD) to those presenting as CBS with corticobasal degeneration pathology (CBS‐CBD). Voxel‐based morphometry was used to compare patterns of gray matter loss in pathologically confirmed CBS‐AD subjects (n = 5) and CBS‐CBD subjects (n = 6) to a group of healthy controls (n = 20), and to each other. Atlas based parcellation using the automated anatomic labeling atlas was also utilized in a region‐of‐interest analysis to account for laterality. The CBS‐AD subjects were younger at the time of scan when compared with CBS‐CBD subjects (median: 60 years vs. 69; P = 0.04). After adjusting for age at time of MRI scan, the CBS‐AD subjects showed loss in posterior frontal, temporal, and superior and inferior parietal lobes, while CBS‐CBD showed more focal loss predominantly in the posterior frontal lobes when compared with controls. In both CBS‐AD and CBS‐CBD groups, there was basal ganglia volume loss, yet relative sparing of hippocampi. On direct comparisons between the two subject groups, CBS‐AD showed greater loss in both temporal and inferior parietal cortices than CBS‐CBD. No regions showed greater loss in the CBS‐CBD group compared to the CBS‐AD group. These findings persisted when laterality was taken into account. In subjects presenting with CBS, prominent temporoparietal, especially posterior temporal and inferior parietal, atrophy may be a clue to the presence of underlying AD pathology. © 2010 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Anatomical differences between CBS‐corticobasal degeneration and CBS‐Alzheimer's disease

Anatomical differences between CBS‐corticobasal degeneration and CBS‐Alzheimer's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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